1268

- October 29 - Conradin, the last legitimate male heir of the Hohenstaufen dynasty of Kings of Germany and Holy Roman Emperors, is executed along with his companion Frederick I, Margrave of Baden by Charles I of Sicily, a political rival and ally to the hostile Catholic church.
- Nicola Pisano completes the famous octagonal Gothic-style pulpit at the Duomo di Siena.
- May 18 - The Principality of Antioch, a crusader state, falls to the Mamluk Sultan Baibars in the Battle of Antioch; Baibars' destruction of the city of Antioch was so great as to permanently negate the city's importance.