1348

- April 7 - Charles University is founded in Prague.

- June 24 - Black Death outbreak in full swing in Melcombe Regis (modern-day Weymouth, Dorset in England)

- July 6 - Papal bull of Pope Clement VI protecting Jews against popular aggressivity during the Black Death epidemic.

- Beginning of Black Death epidemic in central and western Europe

- End of the reign of Emperor Komyo of Japan, second of the Northern Ashikaga Pretenders

- Start of the reign of Emperor Suko of Japan, third of the Northern Ashikaga Pretenders

- May - Black Death reaches England

- Edward III of England creates the first English order of chivalry, the Order of the Garter

- Pskov gains independence from the Novgorod Republic with the treaty of Bolotovo; Pskov Republic formed.

- Black Death in Cairo.

- Estimation: Hangzhou in Mongolian China becomes the largest city of the world, taking the lead from Cairo, capital of Mamluk Egypt.